methylenetetrahydrofolate reductase การใช้

• One of these genes encodes the enzyme Methylenetetrahydrofolate reductase ( MTHFR ).
• Research suggests that epigenetic silencing of MTHFR, the gene encoding methylenetetrahydrofolate reductase, is strongly associated with azoospermic infertility.
• An estimated one-third of adults have both mutant genes, which help produce the enzyme 5, 10-methylenetetrahydrofolate reductase, or MTHFR.
• In the rate-limiting step of the SAM cycle, MTHFR ( methylenetetrahydrofolate reductase ) irreversibly reduces 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.
• However, there are a few exceptions to this general rule, and enzymes such as aldose reductase, glucose-6-phosphate dehydrogenase, and methylenetetrahydrofolate reductase can use both coenzymes in some species.
• The un-methylated form, folic acid ( vitamin B 9 ), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase ( MTHFR ) to become biologically active.